New PDF release: Allergic Diseases

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Adv Immunol 1971; 13:1. Wang B, Reiger A, Kigus O, et al. Epidermal Langerhans cells from normal human skin bind monomeric IgE via FceR1. J Exp Med 1992;175:1353. Kenten JH, Molgaard HV, Hougton M, et al. Cloning and sequence determination of the gene for the human e chain expressed in a myeloma cell line. Proc Natl Acad Sci USA 1982;79:6661. Henry AJ. Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high affinity receptor FceR1. Biochemistry 1997;36: 155568–15578.

The H3 actions of histamine suppress central nervous system histamine synthesis. Increased levels of histamine have been reported in the blood or urine of patients with physical urticaria, anaphylaxis, systemic mastocytosis, and antigen-induced rhinitis and asthma ( 31). Platelet-activating Factor Platelet-activating factor (PAF) is a lipid identified structurally as 1-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine ( 32). This mediator is generated by mast cells, eosinophils, and monocytes. Degradation of PAF occurs by the action of acetyl hydrolase to remove acetate from the sn-2 position.

London: Kluwer Academic Publishers, 1988:29. Galli SJ, Austen KF. Mast cell and basophil differentiation in health and disease. New York: Raven Press, 1989. McGlashan D, Lichtenstein LM, McKenzie-White J, et al. Upregulation of FceRI on human basophils by IgE antibody is mediated by interaction of IgE with FceRI. J Allergy Clin Immunol 1999;104:492–498. Coleman JW, Holiday MR, Kimber I, et al. Regulation of mouse peritoneal mast cell secretory function by stem cell factor, IL-3, IL-4. J Immunol 1993;150:556.

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Allergic Diseases by Patterson

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