By Michael P. Murtaugh PhD, Nancy A. Monteiro-Riviere PhD, Linda Panepinto BS (auth.), Mike E. Tumbleson, Lawrence B. Schook (eds.)
Similarities in constitution and serve as among pigs and humans contain measurement, feeding styles, digestive body structure, nutritional behavior, kidney constitution and serve as, pulmo nary vascular mattress constitution, coronary artery distribution, propensity to weight problems, respiration charges, tidal volumes and social behaviors. because the pig is an omnivore, it presents an adaptable version to judge persistent and acute exposures to xenobiotics equivalent to alcohoL caffeine, tobacco, meals ingredients and environmental toxins. Swine were used effectively as types to judge alcoholism, diabetes, absorption, digestion, overall paren teral foodstuff, organ transplantation, atherosclerosis, workout, high blood pressure. hemorrhagic hypotension, cancer, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal therapeutic and septic surprise. A critical and irritating scarcity of organs and tissues for transplantation in sufferers with critical organ failure has inspired the dignity of inter species or xenotransplan tation. In constructing courses towards this finish, the pig as a rule is seen because the most well-liked donor due to its measurement, body structure and availability. The pig harbors particularly few illnesses that may be transmitted inadvertently to human sufferers. the facility to genetically alter swine to ameliorate the implications of the human immune reaction deals one other major virtue. one other vital attention for an animal version is that uncomplicated biologic again floor info be to be had for investigators to layout destiny potential studies.
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Additional info for Advances in Swine in Biomedical Research: Volume 2
59-162. 62. , 1992, Characterization of lewisite toxicity in isolated perfused skin, Taxical. Appl. Pharmacal. 116:189-201. 63. , 1993, Effects of formaldehyde, DMSO, benzoyl peroxide, and sodium lauryl sulfate on isolated perfused porcine skin, In Vitro Taxieal. 5:251-260. 64. , 1983, Light-induced dermal toxicity: Effects on the cellular and molecular level, in: Dermatotoxicology (F. Marzulli, and H. ) Hemisphere Press, Washington, DC, pp. 323-355. 65. , 1965, A simple microbiological method for demonstrating phototoxic compounds, 1.
In vivo and IPPSF UVB exposures were conducted. In vivo studies were conducted in sedated pigs as described above and the IPPSF's were created, harvested and perfused according to standard protocol. Two IPPSF protocols were used, flaps were either harvested and then exposed in the chamber to UVB or exposed while they were on the pig (in situ), harvested 16 hr after exposure and perfused for 8 hr. Treatments consisted ofUVB doses of 1260 (n = 5), 630 (n = 7), 315 (n = 4) or 0 mJ/cm2 (n = 4). UVB effects were monitored using vascular resistance, glucose utilization, and LM and TEM endpoints.
73 have shown that UVB induced erythema in miniature pigs is comparable to that in humans. No erythema was caused by the in vitro irradiation of the IPPSF since the media lacked red blood cells. However, extravasated and capillary bound red blood cells were present in dermis and directly proportional to dose. This may have been due to a dose dependent release of PGE 2 that subsequently caused vasodilation and increased permeability, thereby releasing red blood cells from underperfused capillary beds.
Advances in Swine in Biomedical Research: Volume 2 by Michael P. Murtaugh PhD, Nancy A. Monteiro-Riviere PhD, Linda Panepinto BS (auth.), Mike E. Tumbleson, Lawrence B. Schook (eds.)