By Frederick W. Alt
Advances in Immunology, a common and hugely revered book, provides present advancements in addition to entire reports in immunology. Articles tackle the wide variety of issues that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored through the main scientists within the box, each one quantity offers updated info and instructions for destiny * Contributions from prime specialists and specialists * Informs and updates on the entire most recent advancements within the box
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Advances in Immunology, a usual and hugely revered booklet, offers present advancements in addition to complete experiences in immunology. Articles deal with the wide variety of issues that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities.
“Nerve-Driven Immunity: Neurotransmitters and Neuropeptides within the Immune procedure” summarizes, analyzes and sheds new mild on an unrecognized, but extremely important position of key neurotransmitters and neuropeptides within the immune process. every one bankruptcy of the publication bargains with a special neurotransmitter/neuropeptide from the next record: Dopamine, Adrenaline, Noradrenaline, Acetylcholine, Glutamate, GABA, Somatostatin, Neuropeptide Y (NPY), Vasoactive intestinal polypeptide (VIP), Calcitonin gene similar peptide (CGRP), Opioids and Cannabinoids.
This quantity specializes in the position of sphingosine-1-phosphate (S1P) and its analogs within the brought on sequestration of lymphocytes in secondary lymphoid organs or within the microenvironment of tissues enthusiastic about an infection or autoimmune sickness. preliminary chapters outline the pathways to appreciate S1P signaling.
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Additional info for Advances in Immunology, Vol. 105
The GM2 activator The GM2AP is the fifth member of the SAP family. GM2AP is larger than saposins A–D, with a molecular weight of 20 kDa in its mature lysosomal form (Furst and Sandhoff, 1992). , 1997). , 1997). The saposin function of GM2AP is required to stimulate the degradation of GM2 by b-hexosaminidase A (Hex-A) in vivo (Fig. 1) (Conzelmann and Sandhoff, 1979). Deficiency in GM2AP leads to the AB variant of GM2 gangliosidosis, an atypical form of Tay–Sachs disease with characteristic tissue accumulation of GM2 and related GSLs in neuronal lysosomes (Conzelmann and Sandhoff, 1978).
Histolytica. Considering that the primary function of amoebapores is the destruction of phagocytosed bacteria for nutritional purposes, a diversity of SAPLIPs might be required for subsequent digestive steps.
1992). This is not surprising considering their important functions in sphingolipid degradation. Protein expression analyses revealed high concentrations of pSAP in the adult liver and body fluids, especially in the brain, semen, milk, serum, pancreatic juice, and bile (Kolter and Sandhoff, 2005). 1 Pathways of GSL degradation. The graph depicts the degradative pathways of various GSL species, including the globo-, isoglobo-, ganglio-, and (neo)lacto-series. The names, formula, and structural icons of the respective GSLs are shown in the boxes.
Advances in Immunology, Vol. 105 by Frederick W. Alt