Advances in Immunology, Vol. 105 by Frederick W. Alt PDF

By Frederick W. Alt

ISBN-10: 0123813026

ISBN-13: 9780123813022

Advances in Immunology, a common and hugely revered book, provides present advancements in addition to entire reports in immunology. Articles tackle the wide variety of issues that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored through the main scientists within the box, each one quantity offers updated info and instructions for destiny * Contributions from prime specialists and specialists * Informs and updates on the entire most recent advancements within the box

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The GM2 activator The GM2AP is the fifth member of the SAP family. GM2AP is larger than saposins A–D, with a molecular weight of 20 kDa in its mature lysosomal form (Furst and Sandhoff, 1992). , 1997). , 1997). The saposin function of GM2AP is required to stimulate the degradation of GM2 by b-hexosaminidase A (Hex-A) in vivo (Fig. 1) (Conzelmann and Sandhoff, 1979). Deficiency in GM2AP leads to the AB variant of GM2 gangliosidosis, an atypical form of Tay–Sachs disease with characteristic tissue accumulation of GM2 and related GSLs in neuronal lysosomes (Conzelmann and Sandhoff, 1978).

Histolytica. Considering that the primary function of amoebapores is the destruction of phagocytosed bacteria for nutritional purposes, a diversity of SAPLIPs might be required for subsequent digestive steps.

1992). This is not surprising considering their important functions in sphingolipid degradation. Protein expression analyses revealed high concentrations of pSAP in the adult liver and body fluids, especially in the brain, semen, milk, serum, pancreatic juice, and bile (Kolter and Sandhoff, 2005). 1 Pathways of GSL degradation. The graph depicts the degradative pathways of various GSL species, including the globo-, isoglobo-, ganglio-, and (neo)lacto-series. The names, formula, and structural icons of the respective GSLs are shown in the boxes.

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Advances in Immunology, Vol. 105 by Frederick W. Alt


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